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What is Lorazepam?
Lorazepam is a medication that is also known under its trade names Ativan or Temesta. Firstly, discovered in 1977, lorazepam was originally used only for treatment of anxiety, but its uses have grown over time and new ones are being found all the time.
Ativan tablets belong to a family of drugs called benzodiazepines. This type of medication is mostly used to treat and manage disorders caused by anxiety, but they can be utilized for other purposes as well. Benzodiazepines have some common effects, while other exact effects vary in the way they work. Because of that it can be used for a variety of treatments. Mostly it is prescribed for patients who suffer from short-term anxieties, seizures, insomnias and it can be even used for pre operation sedation (or pre medication) in hospitals, or in some cases, it has been known to be useful as sedatives for patients who are over aggressive.
This benzodiazepine is relatively strong and is considered short to medium acting. That means that it is usable in cases of acute issues as well as chronic cases. Lorazepam is also notable for possessing all six properties that other benzodiazepines are known for such as antiemetic effects, amnestic effects, medium muscle relaxants, anticonvulsant, sedative and hypnotic properties and perhaps most important very strong anxiolytic properties.
A lorazepam dose and regime need to be set up very precisely and monitored carefully to avoid any possible side effects like increased tolerance to it and eventual addiction. There has been known cases where it was used for various operations and in extreme doses, it can give patient anterograde amnesia. It can also be used for recreational purposes as a hypnotic drug to create a the known “lorazepam high”. This is of course illegal and highly discouraged because any non-standard and non-regulated use can easily lead to some harmful side effects like tolerance, addiction and later withdrawal syndrome. There have also been reports of patients developing paranoia in cases of great abuses.
These are all reasons why this medicine should not be used without being prescribed by your doctor and only with specific instructions and regular controls. If you feel you are suffering from any symptoms that this medicine could help you treat, do not hesitate to seek advice and treatment. However, it is still your doctors’ final call whether you should take it or not. It is a very serious drug with strong effects and can cause many side effects if not used responsibly. So, make sure, to always use it, exactly as prescribed to maximize the positive and minimize negative effects.
How does Lorazepam work?
Lorazepam is an anxiolytic drug belongs to benzodiazepines. Anxiolytic drugs, including Lorazepam inhibit the action of central nervous system (CNS), mainly in the thalamus, hypothalamus and limbic system.
Lorazepam increases the release of gamma-aminobutyric acid (GABA), which is one of the main mediators that inhibit nerve impulses transmission in the CNS. Lorazepam possesses anxiolytic, hypnotic, sedative, muscle relaxant and anticonvulsant effects. It is highly valued since it is one of the faster drugs from the benzo group. However, because it is so potent, it is also considered one of the more addictive drugs.
Mechanism of Lorazepam action is to stimulate benzodiazepine receptors that:
- activate GABA receptors;
- reduce the excitability of the subcortical brain structures;
- slow down polysynaptic spinal reflexes.
Discover Lorazepam mechanism of action in this detailed video below:
While taking this medication, do not take alcohol as it can increase the effects of alcohol. Lorazepam can be habit forming and it is advisable to use it only if it has been prescribed. This drug should never be shared with others especially if they have a history of drug abuse or addiction. Always remember to keep the medication to a safe and secure place where others have access to it.
After oral administration, it is slowly but completely absorbed from the gastrointestinal tract. Maximum concentration in the plasma is achieved about 2 hours after a single daily dose of Lorazepam 2mg. Equilibrium concentration of Lorazepam pills in the plasma is achieved 24-36 hours after oral use.
The lorazepam half-life from the body is approximately 20 hours. It is quickly excreted from the body after the withdrawal. Lorazepam pharmacokinetics in elderly patients (over 65 years) corresponds to Lorazepam pharmacokinetics in patients of middle age. Since the medicine is metabolized mainly by kidneys, patients with kidney dysfunction are recommended to take it with caution.
What is Lorazepam used for?
Ativan tablets are prescribed for:
- treatment of neurosis and neurotic disorders, including depression, accompanied by anxiety and sleep disorders;
- premedication, used one night and (or) 1-2 hours before surgery.
It provides sedative action, reduces neurosis and depressive symptoms, normalizes a patient’s general state and sleep.
It is commonly used to manage anxiety and sleeplessness and it helps people relax before a surgery. Difficulty with falling asleep, frequent interruptions of sleep, decrease of the total amount of sleep time and lack of feeling of relaxation – all these are symptoms of chronic insomnia.
Insomnia is a symptom, which occurs in the neuroses, certain cardiovascular and psychiatric diseases, as well as at violations of the function of the brain responsible for the regular alternation of sleep and wakefulness.
If you do not find out the cause of insomnia, and do not take steps to normalize sleep, then over time this can lead to poor functioning of many organs and human health in general. Modern medicine offers a simple and affordable way to combat insomnia. The newest drugs, the pharmacological effect of which is aimed at improving sleep, provide not only the hypnotic effect, but also contribute to the restoration of natural sleep and wakefulness.
Lorazepam, is prescribed to patients with insomnia, it renders a pronounced tranquilizing effect at the organism, restoring a normal rhythm of sleep. Short course of reception of this medicine will help to change the broken ways of life and human behaviour.
When taking lorazepam for sleep (insomnia), you should be familiar with a proper reception, contraindications to this drug and side effects, which may arise during the course of treatment.
The uniqueness of this drug is that the indications for its use cover even a wider range of diseases and emotional disorders. It is also prescribed for people suffering from the conditions such as insomnia, nervousness, anxiety disorders, posttraumatic stress disorder, phobias of various origins, obsessive-compulsive disorders, psycho reactive states, depression, psychosomatic disorders, headaches, nausea and vomiting (after chemotherapy), epilepsy, chronic alcoholism and alcoholic delirium (as part of complex therapy).
It is also prescribed for other reasons like helping patients from the nausea and vomiting after chemotherapy. There are chances that it can cause amnesia while a person is taking it. Before taking these tablets, one is advised to talk to his or her doctor and tell him if you have glaucoma, kidney or liver disease, breathing problems or a history of depression, suicidal thoughts or any addiction to drugs or alcohol.
What is the proper Lorazepam dosage?
The main administration is orally in the form of pills or tablets. Standard tablets are sold in three variants: 2 mg tablets, 1 mg tablets and 0,5 mg tablets.
The standard dose of lorazepam is considered to 1, 2 or 6 mg daily, in separate doses. They should be divided throughout the day, but the biggest dose should usually be taken before bedtime.
Daily doses can be, depending on the case, from 1 to 10 milligrams. One of the main factors to take under consideration is the state of the patient, the progress of his disorder and his overall health. The Lorazepam dosage:
- For patients who are being treated for anxiety problems, initial dose should be 1 to 3 milligrams daily, distributed through the course of the day in three to four doses.
- In case of anxiety related insomnia, best is if there is only one dose of 2 to maximum 4 mg before bedtime, of course depending on the strength of the attacks.
- Senior patients can sometimes be hypersensitive to benzodiazepines and lorazepam is no exception. Therefore, it is recommended that they take a smaller dose. The starting dose for this population should not be over 1 or 2 milligrams each day.
Those recommended doses should be revaluated every few days (usually three or four), and never by more than half a milligram or one milligram every time. This is mainly to prevent the possibility of any adverse or negative effect like increased resistance to it or a possible addiction. Patient should never take more than the lowest effective dose that is available to him. This is a good way to prevent tolerance and addiction. You should be reminded that this variant is much more potent than other benzodiazepines and if you have experience with them, you should already be aware their doses must be followed exactly. You need to be under regular supervision from your doctor so he can make sure you are doing it right, and your dose is correct.
Giving your physician a complete history will enable your physician to give the correct lorazepam dosage in order to receive the full benefit of the drug and to prevent any harmful reaction. If you know anyone who have a drug addiction please contact drug rehabilitation centres for help.
What are the side effects of Lorazepam?
As with any other medication also there are Ativan side effects. Lorazepam side effects are weakly pronounced and will quickly disappear. Lorazepam side effects may include: dizziness; anxiety; sleep disorder; smooth muscles spasm; increased sweating; nausea; vomiting; tremor; perceptual disorders; photophobia; skin rash and itching.
You could have unpleasant side effects if you stop using it suddenly. In this case, the side effects are more clearly pronounced and are able to harm a patient’s health.
With which substances has Lorazepam interactions?
Its effect on CNS functions increases in simultaneous use with sedatives, tricyclic antidepressants, non-selective MAO inhibitors, muscle relaxants, analgesics, phenothiazines and other neuroleptics.
Lorazepam plasma concentration increases in combination with cimetidine, disulfiram, erythromycin, fluoxetine, as well as with oral contraceptives and drugs that inhibit liver metabolism.
Lorazepam concentration in the plasma decreases in simultaneous use with rifampicin.
Its activity decreases in simultaneous use with MAO inhibitors, respiratory analeptics and psychostimulants.
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What are the precautions that one should take while taking Lorazepam?
It is contraindicated in: hypersensitivity to benzodiazepine derivatives; chronic obstructive pulmonary disease, respiratory failure, obstructive sleep apnea; as well as in children (under 12 years); during pregnancy and breastfeeding.
Do not operate or drive heavy machinery until you know how the drug affects you. Consult It may cause you to feel dizzy or drowsy. There are more chances for this if you are taking other drugs that depress the nervous system such as opioids, anti-anxiety drugs, muscle relaxers, or some anti-nausea medicines. your doctor if you feel drowsy or have dizziness
Do not take this benzodiazepine while pregnant. In pregnant women, Lorazepam can cause birth defects in an unborn baby. While exposed to this medicine in the womb the unborn child may exhibit withdrawal symptoms, like sedation or labored breathing, upon birth. Besides that, it is not recommended to tale this medicine while breast feeding. It can pass through breast milk and cause side effects in the baby.
Do not mix lorazepam and alcohol. Both of them are are tranquilizers and when taken together they can slow down the body’s functioning which may slow down breathing and blood pressure to dangerous levels. sometimes leading to a blackout.
This medicine should be taken with caution due to its potential for physical dependence and addiction. It’s not unlikely to build up a tolerance quickly. People will always use bigger doses to experience the same effects. In the UK tranquilizers are the third most abused substance behind marijuana and prescription opioids. Some users may experience a a feeling of euphoria which make it a pleasurable medicine to many.
Beforing buying Ativan it is also important that you are aware of the dangers of this anxiety medication. Therefore, we advice you to watch the video below:
How does Lorazepam withdrawal happen?
If you have been taking this drug for some weeks, you may experience withdrawal symptoms if you stop it suddenly – which mostly appears as irritability, stomach cramps or upset stomach, trouble sleeping, trembling or shaking, nervousness and even hallucinations and seizures in those who have taken high doses for a long time.
When ceasing the treatment, a specific protocol should be followed in order to prevent the withdrawal syndrome that can have withdrawal side effects similar to those of long-term alcoholics. This protocol includes the same lowering as the original raising was done, this means half to full milligram every three to four days. In case you experience any symptoms that you feel you should not be, or you feel the medicine is not working the way it should, you should contact your doctor immediately, but it is not advised to stop treatment abruptly on your own hand.
Talk with your doctor or nurse about stopping the drug by lowering the dose over time.
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