Description
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What is Citalopram used for?
If you’re suffering from depression, this medicine may be able to help you. It is an antidepressant (mood elevator) from the family of drugs known as selective serotonin reuptake inhibitors or SSRIs. It is commonly used to treat depression, as well as other conditions as determined by a doctor.
Celexa helps to restore the brain’s chemical balance by increasing the supply of a chemical messenger in the brain known as serotonin. It is effectively relieves depression by increasing serotonin levels with little effect on many of the other chemicals in the brain.
How does Citalopram work?
Celexa is a Selective Serotonin Reuptake Inhibitor (SSRI). While these are not completely understood, it seems that these SSRI’s increase the level of serotonin in the brain by preventing the nerve cell releasing it to reabsorb it. In this way, the serotonin is still available to the next nerve cell. Serotonin is a chemical known to elevate mood and prevent depression in sufficient amounts. By adjusting the levels of serotonin, SSRIs allow the brain to return to normal function and establish proper functioning of the brain’s neurotransmitters. Because Celexa doesn’t affect other brain chemicals, it is a safe, effective treatment that will not alter the brain’s other activities.
How long does Citalopram take to work?
To find reliable relief, take Celexa faithfully every day and at the same time each day. Some people will find relief of their symptoms in as little as one week, but full relief will usually take between two and four weeks as the medication stabilizes the serotonin levels in the brain. Because depression is a long-term condition, you should continue to take your regular dosage even after your symptoms go away to ensure they do not return. Most doctors will suggest you continue to take Celexa for several months after the symptoms have stopped.
Because the level of serotonin in the brain varies from person to person, your dosage may need fine-tuned for the best results. If you do not feel relief in a few weeks, a dosage change may be in order. Be patient and remember that Celexa is an excellent long-term treatment and that the overall results will be well worth it.
While there are some mild side effects such as dry mouth, nausea, diarrhea and insomnia, these are usually not severe and most will fade as you adjust to the medication.
What are the Citalopram side effects?
Celexa side effects are usually tolerable and fairly moderate although some of the citalopram side effects are annoyingly common. Arguably the most common and persistent side effect is sexual dysfunction. Studies show that in short-term trials proximally 16% of patients discontinued treatment due to an adverse effect when compared to 8% of patients receiving placebo. In these studies, only 6% of patients prescribed ejaculatory dysfunction compared to 1% of patients on placebo although many physicians report a much higher incidence of this complaint from patients. Orgasmic dysfunction, which is felt to be the female equivalent of ejaculatory disorder is also felt the more common than is reported in formal studies.
Other common Celexa side effects include dry mouth, increased sweating, nausea, somnolence, and insomnia all of which have been incidence of greater than 10%. This incidence needs to be taken in context because in the same studies the incidence of dry mouth, sweating, nausea, somnolence, and insomnia also had a greater than 10% incidence with placebo.
The nausea that is a common side effect when initially starting the medication is usually self-limited and tends to dissipate within 2 to 3 weeks after starting the medication. Most physicians encourage that patients to try to press past this initial nausea knowing that it will often resolve while continuing the medication. Unfortunately, the sexual dysfunction side effects often do not resolve over time and are relatively common reason patients on citalopram as well as other SSRI medications choose to discontinue therapy.
Rare but serious citalopram side effects can include priapism, and increased risk of suicidal ideation and suicide especially in patients under age 25, and what is known as the serotonin syndrome. The serotonin syndrome is not common with the use of citalopram alone but may become more common when citalopram is added to other medications with serotonergic effects. Some herbal medications like St. John’s Wort are best avoided while taking citalopram to avoid serotonin syndrome.
It’s always best to discuss with your healthcare provider side effects of any medication including citalopram side effects. Sometimes side effects may diminish if the dosage is reduced, and citalopram withdrawal can usually be avoided or minimized by a gradual taper rather than abruptly stopping the medication.
How does Citalopram withdrawal happen?
Citalopram withdrawal, also called citalopram discontinuation syndrome, is a phenomenon common to most of the selective serotonin reuptake inhibitor (SSRI) medications. Citalopram is not as likely as the SSRIs with a shorter half-life to cause citalopram withdrawal symptoms but a mild to moderate discontinuation syndrome is quite common. The most common symptoms of citalopram withdrawal include dizziness sometimes even vertigo, pressure in the head, and what are sometimes called brain saps or brain shocks. The latter citalopram withdrawal symptoms can be quite annoying and are sometimes described as electric shock like sensations especially the head and neck area. Other symptoms can include sweating, tremor, confusion, nightmares, insomnia, and nausea.
Another aspect of the discontinuation syndrome can be persistence of the sexual dysfunction, especially orgasmic dysfunction which is commonly a side effect of persons taking citalopram.
Generally, patients taking any of the selective serotonin reuptake inhibitor medications including citalopram should taper and gradually discontinue the medication rather than stopping abruptly. If a dose of several doses of citalopram are forgotten or missed during therapy resuming the medication will usually quickly eliminate the citalopram withdrawal symptoms.
Paroxetine withdrawal and Effexor withdrawal syndromes are more common than citalopram withdrawal because those medications have shorter half-lives. The half-life of the medication is defined as the time it takes for one half of the drug in the bloodstream to be eliminated from the body. Serum half-life of citalopram is about 35 hours making it much less likely to cause citalopram withdrawal symptoms then paroxetine with the half-life of about 24 hours and venlafaxine, the active ingredient in Effexor, with a half-life of as little as 4.9 hours (the active metabolite of venlafaxine is felt have a half-life of approximately 10.3 hours). Citalopram withdrawal syndrome is more likely when a higher citalopram dosage is stopped suddenly than when a low citalopram hydrobromide dosage is stopped.
What are the citaprolam withdrawal symptoms?
If you have been taking the drug for some time now and are getting better, your doctor may suggest a decrease in your regular dose. If you have been feeling better and your anxiety or depression symptoms have subsided, you may be thinking of discontinuing your use. In case you are on your way to coming off the drug, you need to know about citalopram withdrawal symptoms.
SSRI antidepressants like citalopram may cause side effects as well as symptoms during withdrawal stage. It is believed that an SSRI antidepressant can cause a withdrawal syndrome, depending on the half-life of the drug. Citalopram has a high half-life compared to other SSRIs. This means patients using it should expect to experience some disturbing and uncomfortable symptoms when weaning of or suddenly stopping medication.
Patients using citalopram may experience a number of symptoms when they discontinue use suddenly or decrease dosage significantly. These withdrawal or discontinuation problems include:
- Dizzines
- Tiredness or lack of energy
- Headaches
- Confusion
- “Brain shocks” or “brain zaps”
- Tingling sensations
- Lack of appetite
- Moodiness or irritability
- Feeling of light-headedness
- Sleep problems or insomnia
- Burning sensations
- Sweating
- Regular chills
- Nausea or vertigo
- Vivid dreaming or nightmares
You might experience any of the above if your withdrawal or discontinuation of the drug is not supervised or is abrupt. You might also feel mania or a severely “happy” or elated feeling, completely opposite your depressive feelings.
It is also possible to have “freeze frames” when you suddenly feel completely aware of your body and surroundings for a few seconds. In some cases, you might also experience the symptoms citalopram helps you overcome, such as sad thoughts and anxiety. Another possible symptom after weaning off an SSRI is sexual dysfunction such as lack of libido and premature ejaculation.
To be on the safe side, patients must discuss with their doctors any citalopram withdrawal symptoms they feel. It is best not to go off the medication immediately. Most patients say that slowly decreasing dosage can minimize the withdrawal symptoms and can make it easier to deal with coming off medication.
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